Top Accommodations in Santee, South Carolina

We checked thousands of reviews on and to find the best hotels for your stay
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Katerina Kore

Updated: 27 February 2024 · 3 min

Nestled in the very heart of South Carolina, Santee offers a unique blend of natural beauty and Southern charm that captivates visitors from all walks of life. This picturesque town serves as a perfect getaway for those looking to escape the hustle and bustle of city life, offering serene landscapes and a peaceful atmosphere. With a variety of hotels ranging from luxurious resorts to cozy inns, finding the perfect accommodation in Santee has never been easier.

Choosing the right hotel in Santee can significantly enhance your travel experience, allowing you to fully immerse yourself in the local culture and natural beauty. Whether you're here for the renowned golf courses, the breathtaking views of Lake Marion, or the town's rich history, there's a hotel in Santee tailored to your preferences and budget. Recommendations for accommodations include lakeside retreats that offer stunning sunrise views and downtown hotels that put you in the heart of Santee’s charm.

Exploring Santee is an adventure in itself, and having a comfortable, convenient place to rest at the end of the day is essential. From amenities like swimming pools and on-site dining to the warm Southern hospitality that greets you upon check-in, hotels in Santee are designed to make your stay as enjoyable as possible. So, whether you're a nature lover seeking tranquility, an avid golfer, or a history buff, let this guide lead you to the best hotels in Santee for a memorable stay.
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Our Top 6

(Sorted by rating & number of reviews)

1. Comfort Inn & Suites Santee
2. Hampton Inn Santee-I-95
3. Club Wyndham Lake Marion
4. Idyllic Waterfront Escape With Private Boat Dock! Villa
5. Tru By Hilton Santee Hotel
6. Best Western Plus Santee Inn

Lakeside Retreats: Best Hotels in Santee, South Carolina for Water Enthusiasts

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Santee
Jan 16, 2026 - Jan 17, 2026

Comfort Inn & Suites Santee

7.4

Good

(311 Reviews)

+ 113 photos
Comfort Inn & Suites in Santee is another excellent option for families seeking comfort and convenience. With spacious rooms and suites that offer extra room to spread out, families can enjoy a relaxing stay. The hotel features an outdoor swimming pool perfect for cooling off during warm South Carolina days, a fitness center, and a complimentary breakfast to kick-start your morning adventures. Positioned near the heart of Santee, guests have easy access to local attractions and dining options. Comfort Inn & Suites Santee's blend of comfort, location, and value makes it a fantastic accommodation choice for families visiting the area.
Address: 221 Britain Street
Rating: Good 7.4 (311 Reviews)
Rooms: 61
Price: From 117$

Hampton Inn Santee-I-95

9.2

Good

(545 Reviews)

+ 109 photos
Hampton Inn Santee-I-95 is renowned for its family-friendly atmosphere and excellent customer service. Offering comfortable rooms with modern amenities, families can relax and recharge in between their Santee adventures. The hotel provides a complimentary breakfast with a variety of options to please every palate, an outdoor pool for splashing fun, and a fitness center. Its location near I-95 allows for easy access to local attractions, dining, and shopping, making it an ideal base for exploring everything Santee has to offer. Hampton Inn Santee-I-95's commitment to providing a welcoming and comfortable experience makes it a standout choice for families.
Address: 9060 Old Number Six Highway
Rating: Good 9.2 (545 Reviews)
Rooms: 81
Price: From 115$

Family-Friendly Stays: Top Hotels in Santee, South Carolina for Your Next Family Getaway

Santee is not just a haven for water lovers and golf enthusiasts; it's also a fantastic destination for families looking to enjoy a relaxing vacation together. The town boasts a selection of hotels that are not only accommodating to guests of all ages but also close to family-friendly attractions like the Santee State Park and the Santee National Wildlife Refuge. These hotels provide the perfect mix of kid-friendly amenities, such as swimming pools and spacious rooms, along with easy access to outdoor adventure. Below, we spotlight three hotels ideally suited for families visiting Santee.

Club Wyndham Lake Marion

+ 10 photos
Club Wyndham Lake Marion offers a tranquil retreat amidst the natural beauty of Santee. With spacious, well-appointed villas that overlook the serene waters of Lake Marion, guests can enjoy the comfort of modern amenities while being surrounded by nature. Each villa is equipped with a full kitchen, living area, and private balcony, making it an ideal accommodation for families or groups seeking a home-away-from-home experience. The resort features multiple outdoor pools, a fitness center, and easy access to the lake, where guests can indulge in an array of water sports. The on-site activity program ensures that there's never a dull moment, making Club Wyndham Lake Marion a top choice for those seeking both relaxation and adventure.
Address: 401 Bass Drive
Price: From 169$

Idyllic Waterfront Escape With Private Boat Dock! Villa

7.0

Good

(3 Reviews)

+ 34 photos
For those dreaming of a private waterfront getaway, the Idyllic Waterfront Escape offers an unparalleled experience directly on Lake Marion. This exclusive property features its own private boat dock, allowing guests to enjoy the lake at their leisure, whether it's fishing at dawn or sunset cruises. The house is beautifully furnished, with large windows offering panoramic views of the lake. Equipped with modern amenities, a full kitchen, and comfortable bedrooms, it provides a peaceful haven for families or couples. The expansive outdoor area includes a fire pit and BBQ grill, making it an ideal spot for evening gatherings under the stars. This property truly embodies the essence of a lakeside retreat in Santee .
Address: 3524 Princess Pond Rd
Rating: Good 7.0 (3 Reviews)
Price: From 295$

Tru By Hilton Santee Hotel

+ 31 photos
Tru By Hilton Santee combines contemporary design with comfortable accommodations, offering a refreshing stay near Lake Marion. This hotel caters to guests who appreciate a vibrant, energetic atmosphere and modern conveniences. The rooms are smartly designed with free Wi-Fi, large bathrooms, and comfortable beds, ensuring a restful night's sleep after a day of lake activities. Guests can start their day with a complimentary breakfast, enjoy a workout in the fitness center, or relax by the outdoor pool that boasts beautiful lake views. Tru By Hilton Santee is perfect for travelers seeking a stylish and convenient base for their lakeside adventures.
Address: 273 Britain St.
Rooms: 93

Best Western Plus Santee Inn

8.4

Good

(739 Reviews)

+ 92 photos
Best Western Plus Santee Inn is a favorite among families for its convenient location and array of amenities that cater to guests of all ages. This hotel welcomes families with spacious rooms equipped with refrigerators and microwaves, making snack time and meal prep a breeze. Guests can enjoy a complimentary hot breakfast each morning, a large outdoor pool, and a serene garden area perfect for unwinding. Located just a short drive from the Santee State Park, the hotel offers easy access to hiking, bird watching, and exploring the great outdoors. The friendly staff and comfortable accommodations make the Best Western Plus Santee Inn a top pick for families seeking a memorable stay in Santee.
Address: 9059 Old Number Six Highway
Rating: Good 8.4 (739 Reviews)
Rooms: 102
Price: From 106$